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| PMID | Allele | Disease | Population | Drug Names | SNP | Class | Sentence |
|---|---|---|---|---|---|---|---|
| 22479353 | HLA-DRB1 (HLA-DRB1) | lens dislocation | NA | NA | NA | positive | |
| interestingly, our microarray data show that increased expression of inflammatory genes was associated with major clinical features within the mfs patients group; namely severity of the aortic root dilatation (hla-drb1 and hla-drb5 genes; r = 0.56 for both; false discovery rate(fdr) = 0%), ocular lens dislocation (raet1l, ccl19 and hla-dqb2; fold change (fc) = 1.8; 1.4; 1.5, fdr = 0%) and specific skeletal features (hla-drb1, hla-drb5, gzmk; fc = 8.8, 7.1, 1.3; fdr = 0%). | |||||||
| 22479353 | HLA-DQB1*02 | lens dislocation | NA | NA | NA | positive | |
| interestingly, our microarray data show that increased expression of inflammatory genes was associated with major clinical features within the mfs patients group; namely severity of the aortic root dilatation (hla-drb1 and hla-drb5 genes; r = 0.56 for both; false discovery rate(fdr) = 0%), ocular lens dislocation (raet1l, ccl19 and hla-dqb2; fold change (fc) = 1.8; 1.4; 1.5, fdr = 0%) and specific skeletal features (hla-drb1, hla-drb5, gzmk; fc = 8.8, 7.1, 1.3; fdr = 0%). | |||||||
| 22797933 | HLA-D (HLA-D) | astrocytosis | NA | NA | NA | unclassified | |
| activated brain microglia/macrophages and astrocytosis were quantified by morphometric analysis of immunohistochemical stains for cd68, hla-d, cd163, and gfap. | |||||||
| 28244955 | HLA-DR (HLA-DR) | astrocytosis | NA | NA | NA | unclassified | |
| postmortem, we quantified markers of synaptodendritic damage (microtubule-associated protein 2, synaptophysin), microgliosis [human leukocyte antigen dr (hla-dr), ionized calcium-binding adaptor molecule 1], astrocytosis (glial fibrillary acidic protein), and impaired protein clearance (b-amyloid) in frontal cortex, hippocampus, putamen, and internal capsule. | |||||||
| 23144337 | HLA (HLA) | granulomatosis with polyangiitis | NA | NA | NA | unclassified | |
| familial granulomatosis with polyangiitis: three cases of this rare disorder in one indoasian family carrying an identical hla dpb1 allele. | |||||||
| 23740775 | HLA-DPB1*04 | rs26595 | European | rs9277554 | rs9277341 | unclassified | |
| NA | |||||||
| 25172939 | HLA (HLA) | granulomatosis with polyangiitis | NA | NA | NA | unclassified | |
| hla allele variation as a potential explanation for the geographical distribution of granulomatosis with polyangiitis. | |||||||
| 22924899 | HLA-CLASS I (HLA CLASS II) | fetomaternal hemorrhage | NA | NA | NA | unclassified | |
| we presume that the induction of hla class i antibodies is the result of increased fetomaternal hemorrhage during iut, eliciting antibodies in women with an increased susceptibility to alloimmunization. | |||||||
| 23038034 | HUMAN LEUKOCYTE ANTIGEN (HUMAN LEUKOCYTE ANTIGEN) | chalazia | NA | NA | NA | unclassified | |
| the characteristics of mrkc patients include a significantly higher prevalence in women, multiple history of chalazia, close association with meibomitis, the presence of specific human leukocyte antigen association, high propionibacterium acnes detection rates in meibum culture, and the effectiveness of systemic antimicrobial therapy targeting p. acnes. | |||||||
| 31765953 | HLA-G (HLA-G) | neuromyelitis optica spectrum disorder | Brazilian | NA | NA | negation | |
| hla-g ins/del polymorphism and +3142c/g snp are not related to neuromyelitis optica spectrum disorder (nmosd) development, disability status or anti-aquaporin 4 presence in brazilian patients. | |||||||
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