HLA Web Resource for SNPs, Populations, Resources, ADRs, Diseases

About

Extreme complexity in the Human Leukocyte Antigens (HLA) system and its nomenclature makes it difficult to interpret and integrate relevant information for HLA associations with diseases, Adverse Drug Reactions (ADR) Transplantation. PubMed search displays ~144,000 studies on HLA reported from multiple diseases in diverse locations. Currently, IPD-IMGT/HLA database houses data on 28,320 HLA alleles. We developed an automated pipeline with a unified graphical user interface HLA-SPREAD that provides a structured information on SNPs, Populations, REsources, ADRs and Diseases information. Information on HLA was extracted from ~24 million PubMed abstracts extracted using Natural Language Processing (NLP).This resource from 112 countries and 32 ethnic groups provides interesting insights on: markers associated with allelic/haplotypic association in autoimmune, cancer, viral and skin diseases, transplantation outcome and ADRs for hypersensitivity. Summary information on clinically relevant biomarkers related to HLA disease associations with mapped susceptible/risk alleles are readily retrievable from HLASPREAD. This resource is first of its kind that can help uncover novel patterns in HLA gene-disease associations.

Team

Dr. Mitali Mukerji
Dr. Mitali Mukerji

Chief Scientist

Dhwani Dholakia
Dhwani Dholakia

Senior Research Fellow

Ankit Kalra
Ankit Kalra

Data Curator and Researcher

Praveen Sinha
Praveen Sinha

Interaction Designer

Dr. Lipsa Panda
Dr. Lipsa Panda

Visual Science Communicator

Bishnu Raman Misir
Bishnu Raman Misir

Developer

Contact Us

Dr. Mitali Mukerji
Room no-302
CSIR-Institute of Genomics and Integrative Biology
South Campus, Mathura Road
Opp: Sukhdev Vihar Bus Depot
New Delhi 110025.

011-29879487, 29879488

IGIB website : https://www.igib.res.in/

CSIR logo Trisutra csir_logo

Copyright 2022