HLA SPREAD Data Visualization

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PMID	Allele	Disease	Population	Drug Names	SNP	Class
19485844	HUMAN LEUKOCYTE ANTIGEN (HUMAN LEUKOCYTE ANTIGEN)	abacavir	NA	carbamazepine	NA	unclassified
NA
19497038	HLA (HLA)	drug hypersensitivity	Vietnamese	NA	NA	unclassified
frequency studies and a strong genetic association between hla subtypes and susceptibility to drug hypersensitivity have been reported in different ethnic populations.
20110067	HLA (HLA)	minocycline	African	doxycycline	NA	unclassified
NA
21924464	HLA (HLA)	drug hypersensitivity	NA	carbamazepine	NA	unclassified
using the strong hla predisposition in patients with cbz-induced sjs/ten as a model, we aimed to study the use of tcr repertoire in patients with drug hypersensitivity.
21924464	HLA-B*15	drug hypersensitivity	NA	carbamazepine	NA	unclassified
this study establishes the key role of the tcr in the pathogenic mechanism of sjs/ten, explains why some hla-b*1502 carriers are tolerant to cbz, and provides a biomarker profile for drug hypersensitivity.
21924464	HLA-B*15	drug hypersensitivities	NA	carbamazepine	NA	unclassified
despite the strong hla predisposition to drug hypersensitivities, such as hla-b*1502 to carbamazepine (cbz)-induced sjs/ten, it remains unknown whether particular t-cell receptors (tcrs) participate in recognition of small drug/peptide-hla complexes.
22585534	HLA-B*57	drug hypersensitivity	NA	abacavir	NA	unclassified
the antiretroviral drug abacavir (abc) elicits severe drug hypersensitivity reactions in hla-b*5701(+) individuals.
22617051	HLA-B*57	flucloxacillin	NA	didanosine	NA	unclassified
NA
22617051	HLA ASSOCIATED (HLA-ASSOCIATED)	flucloxacillin	NA	didanosine	NA	unclassified
NA
22617051	HLA-B*57	flucloxacillin	NA	didanosine	NA	unclassified
NA

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