Copyright 2024
| PMID | Allele | Disease | Population | Drug Names | SNP | Class | Sentence |
|---|---|---|---|---|---|---|---|
| 10476693 | HUMAN LEUKOCYTE ANTIGEN (HUMAN LEUKOCYTE ANTIGEN) | recurrent miscarriage | Caucasian | NA | NA | unclassified | |
| problemif immunological factors play a role in the pathogenesis of recurrent miscarriage (rm), it is likely that associations between alleles of classical human leukocyte antigen (hla) genes and rm exist. | |||||||
| 11719594 | HLA-G (HLA-G) | recurrent miscarriage | NA | NA | NA | unclassified | |
| hla-g genotypes and pregnancy outcome in couples with unexplained recurrent miscarriage. | |||||||
| 11719594 | HLA-G (HLA-G) | recurrent miscarriage | NA | NA | NA | only_studied | |
| to evaluate the role of polymorphisms at this locus in maternal-fetal interactions, 113 couples with unexplained recurrent miscarriage were genotyped for seven polymorphisms that define 12 hla-g alleles. | |||||||
| 11719594 | HLA (HLA) | recurrent miscarriage | NA | NA | NA | positive | |
| the significant genotype-specific risk in this population suggests that allelic variation in the alpha-2 domain of the hla-g1 isoforms contributes to recurrent miscarriage. | |||||||
| 11925408 | HLA-G (HLA-G) | recurrent miscarriage | NA | NA | NA | only_studied | |
| we investigated the expression of hla-g and nk cell markers in tissue sections from recurrent miscarriage (n = 9) and ectopic tubal pregnancies (n = 5), and two hysterectomy specimens of healthy pregnancy as well as decidual biopsies (n = 9) were used as controls. | |||||||
| 11925408 | HLA-G (HLA-G) | tubal pregnancies | NA | NA | NA | only_studied | |
| we investigated the expression of hla-g and nk cell markers in tissue sections from recurrent miscarriage (n = 9) and ectopic tubal pregnancies (n = 5), and two hysterectomy specimens of healthy pregnancy as well as decidual biopsies (n = 9) were used as controls. | |||||||
| 11925408 | HLA-G (HLA-G) | recurrent miscarriage | NA | NA | NA | unclassified | |
| in contrast, in recurrent miscarriage tissue a sustained nk cell marker expression of both cd56 and cd16 was paralleled by a decreased expression of hla-g. no morphological changes from the blast-like stage were apparent. | |||||||
| 11925408 | HLA-G (HLA-G) | ectopic pregnancies | NA | NA | NA | unclassified | |
| finally, in ectopic pregnancies hla-g expression in the absence of decidual nk cells was associated with a disturbed trophoblast differentiation. | |||||||
| 12721954 | HLA-G (HLA-G) | recurrent miscarriage | NA | NA | NA | negative | |
| recently, a null allele for the most abundant hla-g isoform was associated with recurrent miscarriage in two independent studies, suggesting that reduced levels of the hla-g1 protein may compromise successful pregnancy. | |||||||
| 15070884 | HLA-DRB1*03 | recurrent miscarriage | NA | NA | NA | unclassified | |
| a study of hla-dr and -dq alleles in 588 patients and 562 controls confirms that hla-drb1*03 is associated with recurrent miscarriage. | |||||||
Copyright 2024