Copyright 2024
| PMID | Allele | Disease | Population | Drug Names | SNP | Class | Sentence |
|---|---|---|---|---|---|---|---|
| 26880626 | HLA-B*27 | anterior uveitides | NA | NA | NA | positive | |
| these same quantitative and qualitative differences might also explain why hla-b27-positive acute anterior uveitides can flip-flop between the left and the right eye, after the first attack. | |||||||
| 26888217 | HUMAN LEUKOCYTE ANTIGEN (HUMAN LEUKOCYTE ANTIGEN) | mycophenolic | European | everolimus | NA | unclassified | |
| NA | |||||||
| 26912063 | HLA (HLA) | neurodegenerative diseases | NA | NA | NA | unclassified | |
| we performed a gene co-expression network analysis of microarray expression data from 101 individuals without neurodegenerative diseases to explore regional-specific co-expression patterns in the frontal and temporal cortices for 12 genes (mapt, grn, chmp2b, ctsc, hla-dra, tmem106b, c9orf72, vcp, ubqln2, optn, tardbp and fus) associated with ftd and we then carried out gene set enrichment and pathway analyses, and investigated known protein-protein interactors (ppis) of ftd-genes products. | |||||||
| 27098790 | HUMAN LEUKOCYTE ANTIGEN (HUMAN LEUKOCYTE ANTIGEN) | neurodegenerative diseases | Chinese | NA | rs17587 | unclassified | |
| proteasome subunits (psmb) and transporter associated with antigen processing (tap) loci are located in the human leukocyte antigen (hla) class ii region play important roles in immune response and protein degradation in neurodegenerative diseases. | |||||||
| 30472949 | HLA-CLASS II (HLA CLASS II) | neurodegenerative diseases | NA | NA | NA | unclassified | |
| immunogenetic factors of neurodegenerative diseases: the role of hla class ii. | |||||||
| 30472949 | HLA-CLASS II (HLA CLASS II) | neurodegenerative diseases | NA | NA | NA | unclassified | |
| the involvement of adaptive immunity mechanisms (antigen presentation, t cell response, antibody production) in the development of neurodegenerative diseases remains unclear and requires further research, including more detailed studies of the role of identified hla class ii genetic variants. | |||||||
| 32816165 | HLA (HLA) | neurodegenerative diseases | NA | NA | NA | positive | |
| the number of microglia and activated microglia cells (hla-rd-ir) was increased in patients with neurodegenerative diseases (p < 0.05). | |||||||
| 27741160 | HLA (HLA) | dysbiosis | NA | NA | NA | unclassified | |
| therefore, dysbiosis could represent an important trigger in cd pathogenesis, along with genetic (hla-haplotypes) and environmental factors (antibiotic administration, mode of delivery, and breastfeeding). | |||||||
| 29078267 | HLA (HLA) | dysbiosis | NA | NA | NA | only_studied | |
| in this study, we investigated the effects of age and gut dysbiosis on the development of cns autoimmunity in humanized transgenic mice expressing the ms-associated mhc class ii (mhc-ii) gene, hla-dr2a, and t-cell receptor (tcr) genes specific for mbp87-99/dr2a that were derived from an ms patient. | |||||||
| 29078267 | MHC (MHC) | dysbiosis | NA | NA | NA | only_studied | |
| in this study, we investigated the effects of age and gut dysbiosis on the development of cns autoimmunity in humanized transgenic mice expressing the ms-associated mhc class ii (mhc-ii) gene, hla-dr2a, and t-cell receptor (tcr) genes specific for mbp87-99/dr2a that were derived from an ms patient. | |||||||
Copyright 2024