Copyright 2024
| PMID | Allele | Disease | Population | Drug Names | SNP | Class | Sentence |
|---|---|---|---|---|---|---|---|
| 1625093 | HLA-DRB1*11 | eye disease | NA | NA | NA | positive | |
| only one split of human leukocyte antigen (hla)-dr5, hla-drb1* 1104, showed a statistically significant association with a risk of chronic iridocyclitis (chi-square value = 7.52; p = 0.036 adjusted; odds ratio 3.45); hla-dqa1* 0501 and hla-dqb1* 0301, both in linkage disequilibrium with hla-drb1* 1104, also were significantly associated with eye disease. | |||||||
| 1625093 | HLA-DQA1*01 | iridocyclitis | NA | NA | NA | positive | |
| only one split of human leukocyte antigen (hla)-dr5, hla-drb1* 1104, showed a statistically significant association with a risk of chronic iridocyclitis (chi-square value = 7.52; p = 0.036 adjusted; odds ratio 3.45); hla-dqa1* 0501 and hla-dqb1* 0301, both in linkage disequilibrium with hla-drb1* 1104, also were significantly associated with eye disease. | |||||||
| 1625093 | HLA-DQA1*01 | eye disease | NA | NA | NA | positive | |
| only one split of human leukocyte antigen (hla)-dr5, hla-drb1* 1104, showed a statistically significant association with a risk of chronic iridocyclitis (chi-square value = 7.52; p = 0.036 adjusted; odds ratio 3.45); hla-dqa1* 0501 and hla-dqb1* 0301, both in linkage disequilibrium with hla-drb1* 1104, also were significantly associated with eye disease. | |||||||
| 1625093 | HLA-DRB1 (HLA-DRB1) | iridocyclitis | NA | NA | NA | positive | |
| only one split of human leukocyte antigen (hla)-dr5, hla-drb1* 1104, showed a statistically significant association with a risk of chronic iridocyclitis (chi-square value = 7.52; p = 0.036 adjusted; odds ratio 3.45); hla-dqa1* 0501 and hla-dqb1* 0301, both in linkage disequilibrium with hla-drb1* 1104, also were significantly associated with eye disease. | |||||||
| 1625093 | HLA-DRB1 (HLA-DRB1) | eye disease | NA | NA | NA | positive | |
| only one split of human leukocyte antigen (hla)-dr5, hla-drb1* 1104, showed a statistically significant association with a risk of chronic iridocyclitis (chi-square value = 7.52; p = 0.036 adjusted; odds ratio 3.45); hla-dqa1* 0501 and hla-dqb1* 0301, both in linkage disequilibrium with hla-drb1* 1104, also were significantly associated with eye disease. | |||||||
| 1625093 | HLA-DRB1 (HLA-DRB1) | iridocyclitis | NA | NA | NA | unclassified | |
| patients with both the drb1* 1104 and dpb1* 0201 genes had a 7.7-fold increased risk for chronic iridocyclitis compared with that for other patients. | |||||||
| 1625093 | HLA-DRB1 (HLA-DRB1) | juvenile rheumatoid arthritis | NA | NA | NA | unclassified | |
| although all children with early-onset pauciarticular juvenile rheumatoid arthritis should undergo periodic slit-lamp examinations, those with the hla class ii gene drb1* 1104 are at particularly high risk for eye disease, and we recommend that they be monitored carefully for its evolution. | |||||||
| 1625093 | HLA-DRB1 (HLA-DRB1) | eye disease | NA | NA | NA | unclassified | |
| although all children with early-onset pauciarticular juvenile rheumatoid arthritis should undergo periodic slit-lamp examinations, those with the hla class ii gene drb1* 1104 are at particularly high risk for eye disease, and we recommend that they be monitored carefully for its evolution. | |||||||
| 1625093 | HLA-DRB1 (HLA-DRB1) | eye disease | NA | NA | NA | unclassified | |
| the presence of hla-drb1* 1104 was about four times as specific, but only about one third as sensitive, as antinuclear antibodies in identifying patients at risk for eye disease. | |||||||
| 1680192 | HLA-DQA1*01 | iridocyclitis | American | NA | NA | unclassified | |
| the presence of hla-dqa1*0101 was significantly lower in patients with chronic iridocyclitis than in patients without chronic iridocyclitis (chi 2 = 7.07, p = 0.008, rr = 0.21). | |||||||
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