Copyright 2024
| PMID | Allele | Disease | Population | Drug Names | SNP | Class | Sentence |
|---|---|---|---|---|---|---|---|
| 20173785 | HLA-B4 (BROAD ANTIGEN) | haploidentical transplantation | NA | NA | NA | negation | |
| this analysis showed that in haploidentical transplantation for aml, hla-c group 1 mismatching in the graft vs host direction not only provides a survival advantage over non-nk-alloreactive (kir ligand-matched) transplants (5-year efs 67+-10% vs 17+-5%) but, indeed, also provides the best efs compared with c2 (35+-10%) or bw4 kir ligand mismatches (44+-17%). | |||||||
| 21835146 | HLA MATCHED (HLA-MATCHED) | cyclophosphamide | NA | tacrolimus | NA | unclassified | |
| NA | |||||||
| 24566712 | HLA (HLA) | haploidentical transplantation | NA | NA | NA | unclassified | |
| the host and donor t-cell responses to allogeneic hla molecules are a fundamental obstacle to the successful application of haploidentical transplantation, which results in unacceptably high incidences of gvhd and graft rejection. | |||||||
| 26172479 | HLA MATCHED (HLA-MATCHED) | haploidentical transplantation | NA | NA | NA | unclassified | |
| haploidentical transplantation can extend the opportunity for transplantation to almost all patients who lack an hla-matched donor. | |||||||
| 27404668 | HUMAN LEUKOCYTE ANTIGEN (HUMAN LEUKOCYTE ANTIGEN) | cyclophosphamide | NA | tacrolimus | NA | unclassified | |
| NA | |||||||
| 27724812 | HUMAN LEUKOCYTE ANTIGEN (HUMAN LEUKOCYTE ANTIGEN) | fludarabine | NA | melphalan | NA | positive+negation | |
| NA | |||||||
| 28887808 | HLA MATCHED (HLA-MATCHED) | haploidentical transplantation | NA | NA | NA | unclassified | |
| immune recovery was generally faster under hla-matched sibling donor transplantation than under haploidentical transplantation. | |||||||
| 28978824 | HLA (HLA) | cyclophosphamide | NA | fludarabine | NA | unclassified | |
| NA | |||||||
| 31447852 | HLA (HLA) | haploidentical transplantation | NA | thymidine | NA | unclassified | |
| whilst common principles apply, there are features that are unique to haploidentical transplantation, where hla-mismatching directly impacts on immune reconstitution, and shared vs. non-shared hla-allele can be an important consideration in antigen-specific t cell therapy. | |||||||
| 31447852 | HLA (HLA) | haploidentical transplantation | NA | thymidine | NA | unclassified | |
| in this review, we will discuss the biology of post-transplant t cell immune reconstitution and the impact of hla-mismatching, and the different cellular therapy strategies that can help accelerate t cell immune reconstitution after haploidentical transplantation. | |||||||
Copyright 2024