Copyright 2024
| PMID | Allele | Disease | Population | Drug Names | SNP | Class | Sentence |
|---|---|---|---|---|---|---|---|
| 8288748 | HLA-DRB1*01 | recurrent miscarriages | Danish | NA | NA | positive | |
| in a previous case-control study of women with unexplained recurrent miscarriages we reported that the frequency of women positive for each of the two histocompatibility (hla) types hla-dr1, br and hla-dr3 was increased in a subset of patients with a history of four or more miscarriages. | |||||||
| 8288748 | HLA-DR3 (BROAD ANTIGEN) | recurrent miscarriages | Danish | NA | NA | positive | |
| in a previous case-control study of women with unexplained recurrent miscarriages we reported that the frequency of women positive for each of the two histocompatibility (hla) types hla-dr1, br and hla-dr3 was increased in a subset of patients with a history of four or more miscarriages. | |||||||
| 8288748 | HLA-DR (HLA-DR) | recurrent miscarriages | Danish | NA | NA | unclassified | |
| we related pregnancy outcomes to the mothers' hla-dr type in a prospective study of a well-defined, closely supervised group of 94 women with unexplained recurrent miscarriages who had achieved intra-uterine pregnancy in the course of one of two prospective placebo-controlled trials concerning the efficacy of immunotherapy. | |||||||
| 8288748 | HLA-DRB1*01 | recurrent miscarriages | Danish | NA | NA | positive | |
| the results suggest that danish women with unexplained recurrent miscarriages who are positive for hla-dr1, br and/or -dr3 display a poorer pregnancy outcome than patients negative for these types. | |||||||
| 8288748 | HLA-DR3 (BROAD ANTIGEN) | recurrent miscarriages | Danish | NA | NA | positive | |
| the results suggest that danish women with unexplained recurrent miscarriages who are positive for hla-dr1, br and/or -dr3 display a poorer pregnancy outcome than patients negative for these types. | |||||||
| 9501290 | HLA-C (HLA-C) | recurrent miscarriages | NA | NA | NA | unclassified | |
| hla-c and -bw typing of couples with unexplained recurrent miscarriages. | |||||||
| 9501290 | HLA-C (HLA-C) | recurrent miscarriage | NA | NA | NA | unclassified | |
| since clones of nk-cells are inhibited differently by supertypic epitopes associated with hla-c and -b alleles we found it of interest to study hla-c and -bw polymorphism in 35 couples with recurrent miscarriage and 30 control couples with normal fecundity. | |||||||
| 9501290 | HLA-B4 (BROAD ANTIGEN) | recurrent miscarriage | NA | NA | NA | only_studied | |
| with respect to the hla-bw epitopes recognized by nkb1 clones, in 46% of the couples with recurrent miscarriage none of the spouses carried the hla-bw4 epitope compared with only 17% of the control couples (p < 0.02). | |||||||
| 9501290 | HLA-B4 (BROAD ANTIGEN) | recurrent miscarriage | NA | NA | NA | unclassified | |
| it is concluded that the hla-bw4 epitope is carried more frequently by couples with normal fecundity than couples with recurrent miscarriage. | |||||||
| 9501290 | HLA-B4 (BROAD ANTIGEN) | recurrent miscarriage | NA | NA | NA | unclassified | |
| the fetuses of couples with recurrent miscarriage are thus expected to lack expression of hla-bw4 epitopes on the trophoblast more often than fetuses of normal couples which might be of importance for the inhibition of nk-cell mediated antitrophoblast cytotoxicity. | |||||||
Copyright 2024