Copyright 2024
| PMID | Allele | Disease | Population | Drug Names | SNP | Class | Sentence |
|---|---|---|---|---|---|---|---|
| 23721552 | HLA-DR (HLA-DR) | viremia | NA | NA | NA | unclassified | |
| during decreasing viremia, 31% of pyvan cases were plasma cell-rich and 40% showed tubular hla-dr expression. | |||||||
| 23793098 | HLA-DRB1 (HLA-DRB1) | viremia | NA | NA | NA | unclassified | |
| here, we delineated previously uncharacterized peptide-drb1 restrictions in functional assays and analyzed the host genetic effects of hla-drb1 alleles on hiv viremia in a large cohort of hiv controllers and progressors. | |||||||
| 23793098 | HLA-DRB1*15 | viremia | NA | NA | NA | positive | |
| we found distinct stratifications in the effect of hla-drb1 alleles on hiv viremia, with hla-drb1*15:02 significantly associated with low viremia and hla-drb1*03:01 significantly associated with high viremia. | |||||||
| 23793098 | HLA-DRB1*03 | viremia | NA | NA | NA | positive | |
| we found distinct stratifications in the effect of hla-drb1 alleles on hiv viremia, with hla-drb1*15:02 significantly associated with low viremia and hla-drb1*03:01 significantly associated with high viremia. | |||||||
| 23793098 | HLA-DRB1 (HLA-DRB1) | viremia | NA | NA | NA | positive | |
| notably, a subgroup of hla-drb1 variants linked with low viremia showed the ability to promiscuously present a larger breadth of peptides with lower functional avidity when compared to hla-drb1 variants linked with high viremia. | |||||||
| 23864640 | HLA-B*58 | viremia | NA | NA | NA | positive+negation | |
| the closely related, but less protective, hla-b*58:01 presents similar epitopes, but hla-b*58:01(+) individuals do not generate cd8(+) t cells targeting the kf11-gag epitope, which has been linked to low viremia. | |||||||
| 24084328 | HLA-A*02 | viremia | NA | NA | NA | unclassified | |
| hla-a2, hla-b44 and hla-dr15 are associated with lower risk of bk viremia. | |||||||
| 24084328 | HLA-B*44 | viremia | NA | NA | NA | unclassified | |
| hla-a2, hla-b44 and hla-dr15 are associated with lower risk of bk viremia. | |||||||
| 24084328 | HLA-DRB1*15 | viremia | NA | NA | NA | unclassified | |
| hla-a2, hla-b44 and hla-dr15 are associated with lower risk of bk viremia. | |||||||
| 24084328 | HLA-A*02 | viremia | NA | NA | NA | positive | |
| using multivariate statistics, low risk of bk viremia was associated with matching of hla-a2 [hazard ratio (hr) 0.51, 95% confidence interval (ci) 0.28-0.85], hla-b44 (hr 0.31, 95% ci 0.076-0.85) and hla-dr15 (hr 0.35, 95% ci 0.084-0.93) (p < 0.05), whereas high risk of viremia was associated with male gender (hr 2.38, 95% ci 1.46-4.09, p < 0.001). | |||||||
Copyright 2024