Copyright 2024
| PMID | Allele | Disease | Population | Drug Names | SNP | Class | Sentence |
|---|---|---|---|---|---|---|---|
| 12462708 | DQ2 (HAPLOTYPE) | celiac sprue | NA | NA | NA | unclassified | |
| the pathogenesis of celiac sprue is related to inappropriate intestinal t-cell activation in hla-dq2 positive individuals triggered by antigenic peptides from wheat gluten or prolamins from barley and rye. | |||||||
| 15766274 | DQ2 (HAPLOTYPE) | celiac sprue | NA | NA | NA | unclassified | |
| hla-dq2 predisposes an individual to celiac sprue by presenting peptides from dietary gluten to intestinal cd4(+) t cells. | |||||||
| 15766274 | DQ2 (HAPLOTYPE) | celiac sprue | NA | NA | NA | positive+negation | |
| here we report equilibrium and kinetic measurements of interactions between dq2 and (i) this highly immunogenic multivalent peptide, (ii) its individual constituent epitopes, (iii) its nondeamidated precursor, and (iv) a reference high-affinity ligand of hla-dq2 that is not recognized by gluten-responsive t cells from celiac sprue patients. | |||||||
| 16464085 | DQ2 (HAPLOTYPE) | celiac sprue | NA | NA | NA | unclassified | |
| human leukocyte antigen dq2 is a class ii major histocompatibility complex protein that plays a critical role in the pathogenesis of celiac sprue by binding to epitopes derived from dietary gluten and triggering the inflammatory response of disease-specific t cells. | |||||||
| 16464085 | DQ2 (HAPLOTYPE) | celiac sprue | NA | NA | NA | unclassified | |
| inhibition of dq2-mediated antigen presentation in the small intestinal mucosa of celiac sprue patients therefore represents a potentially attractive mode of therapy for this widespread but unmet medical need. | |||||||
| 16464085 | DQ2 (HAPLOTYPE) | celiac sprue | NA | NA | NA | unclassified | |
| two such ligands were able to attenuate the proliferation of disease-specific t cell lines in response to gluten antigens and, therefore, represent prototypical examples of pharmacologically suitable dq2 blocking agents for the potential treatment of celiac sprue. | |||||||
| 17590341 | DQ2 (HAPLOTYPE) | methylene | NA | glutamine | NA | only_studied | |
| NA | |||||||
| 6186685 | HLA (HLA) | meningococcal infections | NA | NA | NA | unclassified | |
| inherited deficiency of c8 in a patient with recurrent meningococcal infections: further evidence for a dysfunctional c8 molecule and nonlinkage to the hla system. | |||||||
| 6187301 | HLA-DR (HLA-DR) | erythrokeratodermia variabilis | NA | NA | NA | only_studied | |
| the distribution of epidermal langerhans cells (lc) in erythrokeratodermia variabilis (ekv) was investigated using enzyme-histochemical (atpase) and immunohistochemical (anti-t6 and anti-hla-dr) techniques. | |||||||
| 7959963 | HLA-A (HLA-A) | rhabdomyosarcoma | NA | NA | NA | unclassified | |
| hla class i molecules may play a critical role as receptor for oc43 because monoclonal antibody (mab)w6/32 to hla-a, -b and -c specificities completely blocks infectivity in human rhabdomyosarcoma (rd) cells. | |||||||
Copyright 2024