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PMID Allele Disease Population Drug Names SNP Class Sentence
14977950 HLA-DR (HLA-DR) pertussis NA NA NA positive+negation
using mutant strains of b. pertussis, we found that reduction in hla-dr surface expression was due in part to the presence of pertussis toxin whereas the inhibition of ifn-gamma induction of hla-dr could not be linked to any of the virulence factors tested.
14977950 HLA-DR (HLA-DR) strains NA NA NA positive+negation
using mutant strains of b. pertussis, we found that reduction in hla-dr surface expression was due in part to the presence of pertussis toxin whereas the inhibition of ifn-gamma induction of hla-dr could not be linked to any of the virulence factors tested.
14977950 HLA-DR (HLA-DR) pertussis NA NA NA unclassified
these data demonstrate that b. pertussis utilizes several mechanisms to modulate hla-dr expression.
14977950 HLA-DR (HLA-DR) infection NA NA NA unclassified
bp338 infection reduced cell surface expression of hla-dr and cd86 but not that of major histocompatibility complex class i proteins.
14977950 HLA-DR (HLA-DR) infection NA NA NA unclassified
bp338 infection also prevented gamma interferon (ifn-gamma) induction of hla-dr protein synthesis.
24599530 MHC (MHC) pertussis NA NA NA unclassified
here, we elucidate for the first time the dominant major histocompatibility complex (mhc) class ii-presented b. pertussis cd4(+) t cell epitopes, expressed on human monocyte-derived dendritic cells (mddc) after the processing of whole bacterial cells by use of a platform of immunoproteomics technology.
24599530 HLA-DR (HLA-DR) pertussis NA NA NA unclassified
pertussis epitopes identified in the context of hla-dr molecules were derived from two envelope proteins, i.e., putative periplasmic protein (ppp) and putative peptidoglycan-associated lipoprotein (pal), and from two cytosolic proteins, i.e., 10-kda chaperonin groes protein (groes) and adenylosuccinate synthetase (ass).
28008331 HLA-DR (HLA-DR) pertussis NA prostaglandin NA unclassified
omvs were benchmarked against licensed vaccines, including bexsero and whole cell pertussis formulations, with respect to th-polarizing cytokine and prostaglandin e2 production, as well as cell surface activation markers (hla-dr, cd86, and ccr7).
31507615 HLA-DR (HLA-DR) pertussis NA NA NA unclassified
however, co-culture of b. pertussis-stimulated mo-mph and autologous nk cells resulted in high amounts of ifng secretion and an increased frequency of il-2ra+ and hla-dr+ nk cells, indicating nk cell activation.
31951773 HLA-CLASS II (HLA CLASS II) pertussis NA NA NA lack_of_evidence
reduced binding affinity to hla class ii was observed for the detolerized variants compared to the wild-type peptides, highlighting the potential of this approach for designing more efficacious pertussis vaccines.
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