Copyright 2024
| PMID | Allele | Disease | Population | Drug Names | SNP | Class | Sentence |
|---|---|---|---|---|---|---|---|
| 14512310 | HUMAN LEUKOCYTE ANTIGEN (HUMAN LEUKOCYTE ANTIGEN) | stem cell transplantation | NA | NA | NA | unclassified | |
| despite the success of human leukocyte antigen (hla) typing in allogeneic stem cell transplantation (sct) it is rare to find an unrelated donor that is perfectly matched, making identification of "permissive" mismatches of paramount importance. | |||||||
| 14515723 | HLA IDENTICAL (HLA-IDENTICAL) | fludarabine | NA | melphalan | NA | positive | |
| NA | |||||||
| 14550813 | HLA (HLA) | stem cell transplantation | NA | NA | NA | unclassified | |
| a ctl epitope from human cytomegalovirus ie1 defined by combining prediction of hla binding and proteasomal processing is the target of dominant immune responses in patients after allogeneic stem cell transplantation. | |||||||
| 14604278 | HLA IDENTICAL (HLA-IDENTICAL) | stem cell transplantation | NA | NA | NA | unclassified | |
| the graft-versus-leukemia (gvl) effect of hla-identical allogeneic stem cell transplantation is mainly mediated by alloreactive t-cells directed at the minor histocompatibility antigens (h ags) expressed on the leukemic cells of the recipient. | |||||||
| 14633790 | HUMAN LEUKOCYTE ANTIGEN (HUMAN LEUKOCYTE ANTIGEN) | stem cell transplantation | NA | NA | NA | only_studied | |
| in section ii, prof. anne dickinson and colleagues describe genetic polymorphisms outside the human leukocyte antigen (hla) system that determine the nature of immune reconstitution after allogeneic stem cell transplantation (sct) and thereby affect transplant outcomethrough gvhd, gvl, and transplant-related mortality. | |||||||
| 14648025 | HLA IDENTICAL (HLA-IDENTICAL) | stem cell transplantation | NA | NA | NA | unclassified | |
| minor histocompatibility peptides (mhps) derived from polymorphic segments of endogenous proteins are thought to be targets for graft-versus-host and graft-versus-leukemia reactions after hla-identical stem cell transplantation. | |||||||
| 14669540 | HLA IDENTICAL (HLA-IDENTICAL) | stem cell transplantation | NA | fludarabine | NA | unclassified | |
| the patients were either younger than 55 but unsuitable for standard allogeneic stem cell transplantation because of co-existing disease, or between the ages of 55 and 70, and they had to have either a hla-identical donor relative or a donor in which there was only one mismatched antigen. | |||||||
| 14701704 | HUMAN LEUKOCYTE ANTIGEN (HUMAN LEUKOCYTE ANTIGEN) | stem cell transplantation | NA | NA | NA | unclassified | |
| certain cytokine gene polymorphisms have been shown to correlate with outcome of human leukocyte antigen (hla) identical sibling donor stem cell transplantation (sct), but in unrelated donor sct such information is scarce. | |||||||
| 14730337 | HLA MATCHED (HLA-MATCHED) | etoposide | NA | melphalan | NA | negative | |
| NA | |||||||
| 14740509 | HUMAN LEUKOCYTE ANTIGEN (HUMAN LEUKOCYTE ANTIGEN) | stem cell transplantation | NA | NA | NA | unclassified | |
| in recent years, umbilical cord blood has emerged as an alternative source of hematopoietic progenitors (cd34+) for allogeneic stem cell transplantation, mainly in patients who lack an human leukocyte antigen-matched marrow donor. | |||||||
Copyright 2024